Implications of NAD+boosters in translational medicine

PRSS3/mesotrypsin in prostate cancer progression: implications for translational medicine.

P rostate cancer morbidity and mortality are caused by metastasis to other vital organs and tissues. Metastatic prostate cancer is a terminal disease in need of improved therapies. Hockla et al. have identified prostate cancer cell upregulation of the digestive protease PRSS3/mesotrypsin in association with metastasis and recurrence. Gene silencing of PRSS3 led to pronounced reductions in invas...

The Many Meanings of Evidence: Implications for the Translational Science Agenda in Healthcare

Health systems across the world are concerned with the quality and safety of patient care. This includes investing in research and development to progress advances in the treatment and management of individuals and healthcare organisations. The concept of evidence- based healthcare has gained increasing currency over the last two decades; yet questions persist about the time it takes for new re...

Antioxidants in Translational Medicine

SIGNIFICANCE It is generally accepted that reactive oxygen species (ROS) scavenging molecules or antioxidants exert health-promoting effects and thus their consumption as food additives and nutraceuticals has been greatly encouraged. Antioxidants may be beneficial in situations of subclinical deficiency and increased demand or acutely upon high-dose infusion. However, to date, there is little c...

Translational Medicine

Perspectives of Translational Medicine

Recently, we had a well-moderated, multidisciplinary discussion on perspectives of translational medicine including experts from both the United States and China through the WeChat group for Translational Perioperative and Pain Medicine (TPPM) hosted by Dr Renyu Liu, the interim Editor-in-Chief of TPPM. This proved to be an effective approach in promoting international academic exchanges and di...